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রবিবার, ৬ মে, ২০১২
Researchers tinker with bird flu: Are enough safeguards in place?
A new study and one to be published soon on Asian bird flu have prompted debate about safeguards during research and how much access others should have to research details.
A new study involving a genetically modified flu virus has put a spotlight on calls for tighter international oversight of biomedical research whose bugs pose a high risk of global disease outbreak if released accidentally, by terrorists, or by a rogue individual.
Skip to next paragraphIt's one of two such studies ? the second to be published soon ? that have been at the center of a debate over how heavily to censor research results to avoid publishing details that could make it easier for individuals or countries to increase a virus's ability to spread among organisms it currently can't infect.
The study aimed to answer the question: How radically would a virus that scientists have linked to Asian bird flu need to evolve in order to readily spread among humans, something it rarely does now? To answer the question, the scientists genetically modified the virus until they hit on a combination of changes that could enable it to spread readily among ferrets ? a lab stand-in for humans.
A team led by University of Wisconsin virologist Yoshihiro Kawaoka found that only four changes to the virus's genetic makeup give it the traits to spread among ferrets.
The virus's potential for spread among humans is of keen interest to public-health officials. Since 2003, the World Health Organization has recorded 600 cases involving the Asian bird flu virus in humans. While the number is small, of those cases, nearly 60 percent were fatal, according to the WHO data.
With such a high fatality rate, researchers and public-health officials are concerned that if the virus mutates, the consequences could eclipse those of a global flu pandemic in 1918, a touchstone event in the annals of infectious disease. The pandemic is estimated to have killed between 20 million and 50 million people worldwide, according to the Centers for Disease Control and Prevention in Atlanta.
Understanding the potential for such genetic mutations in the virus, which can evolve rapidly, could help scientists spot a more virulent form early and point to vaccines and other treatments tailored to halt its spread, the study's researchers say.
Dr. Kawaoka's team worked with a lab-created hybrid version of the virus. None of the ferrets affected died. Even so, the genetic changes that appear to ease its spread could plausibly appear in strains outside the lab, other researchers say.
The formal report on the results appears in Thursday's issue of the journal Nature. A second research paper on the topic, from a team led by Ron Fouchier, a scientist at the Erasmus Medical Center in Rotterdam, Netherlands, is slated for publication in an upcoming issue of the journal Science. Dr. Fouchier's team reportedly has used the original virus for its experiments, instead of a hybrid.
Much of the debate surrounding the papers has focused less on whether such work should be done and more on safeguards during the work and access to the details.
After reviewing drafts of the papers last fall that the two teams aimed to publish, the US National Science Advisory Board for Biosecurity (NSABB) recommended last December that the papers be published, but with key details removed to make it harder to use the information to turn the virus into a weapon. At the end of March, the board reversed its recommendation after a panel of experts convened by the World Health Organization reviewed the studies and supported the global public-health case for publishing the papers in their full form. Also, the teams revised their papers to clarify points, including biosafety measures that the researchers used to guard against accidental release.
Discussions about adequate oversight of research into contagious diseases with the potential for global reach in the post 9/11 era have been ?perking along, but nothing has happened," says Lynn Klotz, senior science fellow with the Center for Arms Control and Non-Proliferation in Washington. Meanwhile, the research itself has moved ahead.
?The truth of the matter is that we never hear about these things? until the research ?is done and published,? he says.
At the end of March, the US government adopted policies to more closely monitor ?dual use research of concern? involving 15 organisms or toxins that are deemed to pose the greatest potential threat to people or economic sectors such as agriculture. But those policies apply only to studies that the federal government conducts or funds.
While terrorism remains a concern, Dr. Klotz and others argue that accidental release poses the more significant immediate risk.
Testifying April 26 before the Senate Committee on Homeland Security and Governmental Affairs, Tom Inglesby, director of the Center for Biosecurity of the University of Pittsburgh Medical Center, noted that in 2004, when memories of the SARS outbreak were still fresh, researchers at three labs in Asia inadvertently infected themselves with that virus. In one case, he told the panel, the researcher passed the virus along to others outside the lab, which had many layers of biosecurity measures to prevent organisms from escaping.
?Clearly, mistakes are made and accidents happen, even at high-containment labs during times of extraordinarily heightened awareness and caution,? he said.
The work done on Asian bird flu ?is of scientific interest,? Klotz acknowledges. ?But since the potential of pandemic would be so horrific, it's a scientific interest that shouldn't be pursued except under the most extreme safety conditions.?
For instance, Klotz argues for designing high-biosecurity lab facilities with a space-station-like approach to staffing. Scientists conducting the research would rely on teams of highly trained, well-paid technicians working at a lab for two to three weeks at a time before rotating out. At the end of a research stint, the outgoing team would remain in quarantine inside the facility for another week to ensure they are not inadvertently carrying the organisms they were working with.
Given the global nature of a pandemic, John Steinbruner, director of the University of Maryland's Center for International and Security Studies at Maryland, calls for the World Health Organization to regulate research into the pathogens that scientists have deemed the deadliest. He cites WHO oversight of smallpox research as an example already under way. Only two labs in the world ? one in the United States, the other in Russia ? are sanctioned to conduct the research.
Dr. Steinbruner's approach calls for an international panel of scientists that would approve research proposals, identify the people who should have full access to the methods and results, and ?hold those vetted individuals accountable for what they do with the information,? he wrote in Nature in January, as the debate over the initial NSABB recommendations heated up.
?We really do need to bring research on potential pandemic pathogens under international monitoring, and there probably should only be two or three labs in the world that do this kind of stuff,? Klotz says.
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i Learn With ? Planet Boing! HD for iPad review
i Learn With - Planet Boing! HD is part of a series of iPad apps that combine learning with fun for toddlers and young children. This particular app in the series is great for the younger players and is the central zone for both parents and kids with a free-play environment filled with lots of bright colors, music, and interactivity.
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শনিবার, ৫ মে, ২০১২
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Adam Yauch Remembered By Justin Timberlake, Travis Barker
Tributes for the late Beastie Boys MC flooded Twitter on Friday.
By Jocelyn Vena
Adam Yauch in 1999
Photo: Mick Hutson/ Getty Images
Beastie Boys founding member Adam Yauch, a.k.a. MCA, died Friday (May 4) at age 47 after a nearly three-year battle with cancer. News of the MC's death quickly spread across the Internet, and the tributes that flooded Twitter showed the impact his music had on artists from all areas of entertainment.
"Crushed to hear the news of Adam Yauch's passing," Justin Timberlake tweeted. "A true pioneer of art. My thoughts and prayers are with his family and loved ones.#RIPMCA"
He's not the only member of the pop world feeling the loss: The Ryan Tedder-led band, OneRepublic, also expressed their shock over his death. "R.I.P Adam MCA," the band wrote. "Beastie Boys remain untouchable."
DJ Steve Aoki expressed his sadness, writing, "Ahhh man... rest in peace to the one and only MCA. wow. terrible news."
"Rip MCA," the Backstreet Boys chimed in. "Our thoughts are with you and your family. #BeastieBoys4Life."
Given how influential the band had been across all genres and their own roots in rock, the reaction has been overwhelming in the rock-and-roll community. "Rest In Peace Adam Yauch /MCA," Blink-182's Travis Barker tweeted. "4ever somebody i looked up to & had the pleasure of meeting. Damn this bums me out, we lost one of the best."
Fellow drummer Chad Smith, from the Red Hot Chili Peppers, added, "Wow, lost another brother..sail on MCA."
Jimmy Eat World tweeted, "We're very saddened by the passing of Adam Yauch. RIP MCA. You'll be missed." They also tweeted a link to the Beasties' track "Gratitude," from their 1992 album, Check Your Head.
"We're sad to learn about the death of MCA," Linkin Park tweeted. "Our condolences to the Beastie Boys and Adam's family."
On top of his music, Yauch had also become a film director and producer over the past decade, so Hollywood felt the loss as well. "RIP Adam Yauch," director Kevin Smith tweeted. "You made my teenage years more fun and your art made it easier for me to do what I do. For a Beastie, you sure were a beaut."
"RIP Adam Yauch (MCA of the Beastie Boys). He was a super-genius, a visionary and, most importantly, a really good person," Rainn Wilson noted.
"Rest in peace Adam Yauch," Marlon Wayans added. "Beastie Boys were always the 'coolest whiteboys' when I was growing up. They erased color lines the opposite way."
Share your condolences for MCA's family, friends and fans in the comments below.
Tune in to MTV tonight at 8 p.m. as Sway hosts an hour-long special celebrating the life and career of Adam "MCA" Yauch, including the late Beastie Boy's biggest moments and remembrances from his friends and peers. Check out mtvU now for the Beastie Boys' classic music videos.
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শুক্রবার, ৪ মে, ২০১২
Junior Seau 911 Call: Megan Noderer, Girlfriend of NFL Great, Discovers His Suicide
Megan Noderer, Junior Seau's girlfriend, called 911 shortly after discovering the future NFL Hall of Famer dead of apparent suicide Wednesday morning.
Police have ruled Junior Seau's death a suicide after he shot himself in the chest at his Oceanside, Calif., home, a suicide, so the 911 call isn't surprising.
It is as horrific and tragic as it gets, though. Be forewarned, as Nodereris so hysterical during the call she can hardly speak after finding Junior:
Megan tells the dispatcher that the 43-year-old athlete wasn't breathing when she arrived and had appeared to have shot himself "in the heart."
Authorities responded and attempted to revive Seau, but life-saving efforts were unsuccessful. Seau was soon pronounced dead on the scene.
Seau's family claims he exhibited no signs of depression before his death, but has since donated his brain to be studied for concussion research.
The star's tragic, shocking passing has renewed the serious debate over the link between pro football and lasting brain injuries to its players.
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'Cosmopolis' Clip: Robert Pattinson Is Not Quite The Charmer
Robert Pattinson's "Cosmopolis" character Eric Packer sure knows how to charm a lady. The first full clip from the movie has been released courtesy of Allocine, and in it we see Packer trying— albeit unsuccessfully— to seduce Sarah Gadon's character Elise Shifrin. The two had met before the snippet begins in a bookstore, and it's [...]
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Waze Makes Its First Step Beyond The Phone, Integrates With Pioneer AppRadio
The makers of traffic app?Waze?are the latest company wanting to go beyond the phone and integrate more deeply with car hardware. It's a natural move ? if you use Waze, you use it when you're driving. However, the whole dealmaking and integration process with automakers is long and complicated, so as a first step, Waze is looking at the "aftermarket" of devices that people can add to their cars. And it's starting with?Pioneer's AppRadio.doj dept of justice weather chicago swizz beatz mpaa south carolina debate lauren scruggs
Lorne Michaels Knows "There Will Be" 'SNL' Cast Changes
Attention all Saturday Night Live fans, the show's creator-producer Lorne Michaels is officially warning you that, yes, there will definitely be some changes to the cast lineup next season.
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বৃহস্পতিবার, ৩ মে, ২০১২
LG announces Optimus LTE2, coming to Korea mid-May with True HD IPS and 2GB RAM
Unlike today's other phone announcement, we can't say we were expecting to see LG come out with something of its own -- and it's a bit of a doozy, at that. Samsung's Korean rival decided not to let the Galaxy S III have the full spotlight for long, officially unleashing the Optimus LTE2. The mind-blowing portion of the spec sheet is its inclusion of 2GB RAM, a milestone we haven't yet seen in a smartphone. Additionally, the LTE2 will feature the company's "True HD IPS" display, WPC-backed wireless charging capabilities, Android 4.0 and a 2,150mAh battery that LG claims will increase the battery life by an astounding 40 percent. We haven't received word on which CPU will be used, though we're hopeful that a quad-core beast (or Krait, perhaps?) will complement the astounding amount of RAM. The LTE2 is due to land on at least three carriers in Korea sometime in mid-May, but we haven't heard any pricing or additional country availability at this time. We'll keep you posted as we learn more. In the meantime, check out LG's Flickr page down below for more images, and start thinking of ways to take advantage of the extra horsepower.
LG announces Optimus LTE2, coming to Korea mid-May with True HD IPS and 2GB RAM originally appeared on Engadget on Thu, 03 May 2012 19:31:00 EDT. Please see our terms for use of feeds.
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Video: Yep, That?s a Lemon Shark With a Green Laser Attached
Lest you didn't believe Tuesday's report of a laser-equipped shark swimming off the coast of the Bahamas, Wicked Lasers, the company that sponsored the experiment, has published video of the only slightly evil fish in action.
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The Ultra-Modern Chair That's All About Old-School Carpentry [Beautiful]
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Get Satisfaction Wants To Spread Community (Widgets) Everywhere With Engage
Get Satisfaction was built around the importance of community to businesses. Now, with the launch of a new product called Get Satisfaction Engage, it wants to make those communities embeddable anywhere. Basically, Engage is a new architecture for Get Satisfaction widgets, turning them into customizable versions of a company's Get Satisfaction community. People can browse the new widgets without leaving whatever web page they're on. That means all the discussion among a company's customers, users, and fans will become more useful to people who aren't a part of that community ? including in a several contexts outside beyond the customer support arena where Get Satisfaction first made its name.sam shepard sam shepard johnny knox johnny knox monday night football monday night football bonjovi
Weebly Adds Slick iOS App To Its Quietly Huge Web Site Creation Business
I keep hearing rumors about the ridiculous amounts of money that Weebly is making. But the San Francisco company, which provides a set of tools for small businesses and other organizations to easily create their own web sites, has only scoffed at the nine-figure amounts I've thrown at them. Instead, they've shared something else -- a new mobile app that lets new users quickly create their own sites, or existing folks manage what they have going. In a series of quick swipes, it lets you get through naming a site, upload images, choosing a theme, and publishing your first post. If you want to get fancier, you can also take photos and alter them with a set of filters, or shoot videos to publish.billy cundiff super bowl tickets superbowl birmingham news lee evans lee evans 49ers
Unofficial Hotshoe for the Sony NEX-5/5N
Have a Sony NEX-5/5N?? Don’t you just wish it had an actual hotshoe instead of Sony’s proprietary accessory port?? NEX Pro Shop just released an unofficial hotshoe adapter to fit in your Sony NEX-5/5N.? The Shadow allows you to connect an off camera flash and have it triggered by the NEX-5/5N.? It’s priced at $79.99 [...]
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মঙ্গলবার, ১ মে, ২০১২
Remodeling Your Home the Right Way |
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One of the most enjoyable things you can do within your own home is remodeling. You can drastically increase the charm and value of your home, plus make it look entirely different by doing some repairing and modernizing. On the other hand, before you initiate any remodeling projects, there are some really important things you should focus on and those are what we will be discussing in this article.
Typically, if you wish to make sizable improvements to your home, than you need a permit. This fluctuates in different areas, so it is essential for you to find out about this before you embark on any home improvement projects. Or else you increase your probability of getting fined from your city or town when someone finds out. If you make a phone call to your local government offices, you should ordinarily be able to find out whatever it is you need to know. If you decide to have a licensed contractor work for you, he will ordinarily look after these matters for you, although if you are paying a casual laborer or handyman to do the work for you, then it will be up to you to look into these matters. Ordinarily, obtaining a permit should not be an obstruction with your construction however in order to avoid any future issues, this is something you do not want to ignore.
If you?re on a tight budget, you may be able to find creative ways to remodel your home on the cheap. There are certain essential home improvements that you can?t really skimp on (e.g. a new roof), but many smaller projects can be done quite reasonably. Shop around at yard sales, flea markets, antique shops and local auctions for interesting lighting fixtures, doors, furniture, rugs, artwork and other items.
You never know what might make a difference in a room -perhaps an antique mirror, a landscape painting or a set of chairs you got a good deal on at a local auction. Nor should you overlook the millions of possibilities you can find online every day. You can often find good deals on older items on eBay, though it?s best to avoid bidding wars.
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Final Reflections ? Next Step Interning In Israel ? BUSINESS ...
By Jennifer Glick
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In April of your senior year of high school, you make a seemingly life or death decision: where you want to go to college.? By this point in my senior year I had already participated in a dozen college interviews, visited numerous college campuses and still did not know where I wanted to go.? When I visited Washington University in St. Louis that April, I hoped for a sign to tell me that Wash U was the right place for me, and I got one.? My father and I chanced upon an informational meeting for Business, Innovation and Entrepreneurship in Israel, and we simultaneously decided that I belonged at Wash U.
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The actual course more than lived up to my expectations: we heard from numerous influential guest speakers, learned about the economic history of Israel, and visited many of the places in our readings over spring break, when we traveled to Israel.? I had previously visited Israel with my family, but this trip was an entirely different experience.? Israel?s expertise in the business sector, especially in high-tech sectors, combined with the willingness of Israelis to share their personal and professional stories, resulted in a trip perspective unlike any other I previously experienced.
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Many of the presentations fascinated me, but the Zell Program at the IDC stood out as one of the most memorable events during the trip.? The Zell Program helps young entrepreneurs to launch their ideas, and two of the participants walked us through their innovative product, called Hoc Spot.? Hoc Spot allows people in the same room to easily share files without the need to collect contact information.? The two presenters were extraordinarily passionate about their work, and this passion kept the audience engaged.? Although I do not aspire to be an entrepreneur, I greatly enjoy hearing about the innovative ideas of others.
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Visiting the Kotel on Shabbat was also an extremely meaningful experience.? Although the evening was cold and rainy, a large group of Israeli soldiers danced and sang in front of the Western Wall.? We read, of course, about the religious significance of Jerusalem, but watching those soldiers made all of our readings come alive.? It is important to remember that even though our course focused mainly on the business side of Israel, there are many other factors, including religion, that impact Israeli economics.
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This course taught me a significant amount about business in Israel, and I hope to continue learning about this field in the future.? The class also inspired me to search for internships abroad, and I now plan to intern in Israel next summer.? I will never stop learning about Israel, and this course allowed me to learn about Israel from a business perspective.? It was a great class with an unforgettable trip, and I gained so much from participating in the experience.
Jennifer ? Olin Business School ? Sophomore ? Illinois
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